If you notice blood in your urine, painful urination, persistent pelvic discomfort, unexplained weight loss, or significant changes in urinary function, arrange a medical evaluation rather than trying to treat the symptoms with supplements.
There are also situations that require urgent attention. If you suddenly cannot urinate despite having a strong urge, particularly if you have significant lower abdominal pain, seek urgent medical care. A complete inability to urinate can require immediate treatment.